Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4

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Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4.

The specific reaction of potassium permanganate with thymine in single-stranded DNA was employed to analyze thymine [2+2] dimer repair in DNA and in DNA/peptide nucleic acid hybrid duplexes. This simple and highly sensitive chemical assay is convenient for monitoring repair of thymine dimers in oligonucleotides.

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 1998

ISSN: 1362-4962

DOI: 10.1093/nar/26.17.3940